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研究生: 孫雨彤
Sun, Yu-Tung
論文名稱: 雲端睡眠判讀平台功能強化及其應用於睡眠技師判讀一致性提升之訓練效益
Enhancement of a Cloud-Based Sleep Scoring Platform and Evaluation of Its Training Effectiveness in Improving Interscorer Agreement Among Sleep Technologists
指導教授: 梁勝富
Liang, Sheng-Fu
學位類別: 碩士
Master
系所名稱: 電機資訊學院 - 醫學資訊研究所
Institute of Medical Informatics
論文出版年: 2026
畢業學年度: 114
語文別: 英文
論文頁數: 100
中文關鍵詞: 睡眠多項生理檢查 、睡眠判讀 、判讀者間一致性 、雲端睡眠判讀平台 、睡眠呼吸中止特異性缺氧負荷
外文關鍵詞: polysomnography, sleep scoring, interscorer agreement, cloud-based sleep scoring platform, sleep apnea-specific hypoxic burden
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  • 睡眠多項生理檢查(polysomnography, PSG)為睡眠疾病診斷與鑑別的重要工具,其結果仰賴睡眠技師依美國睡眠醫學學會(American Academy of Sleep Medicine, AASM)準則進行睡眠分期與事件標記。然而,真實臨床個案常包含非典型波形、睡眠片段化及複雜事件,即使已有標準化規則,不同判讀者仍可能產生差異,進而影響睡眠報告與下游臨床指標。既有研究已證實雲端平台結合專家訓練可提升單一年度之 PSG 判讀一致性,但對平台長期維運、跨年度不同臨床主題之應用,以及新判讀項目與臨床指標之持續擴充,仍缺乏系統性評估。
    本研究承接既有雲端睡眠判讀平台,配合 2025 與 2026 年全國睡眠判讀工作坊之臨床與教學需求進行功能強化,包括快速動眼期肌肉未失張(REM sleep without atonia, RSWA)標記與比對、多次入睡潛伏期試驗(multiple sleep latency test, MSLT)訊號、開關燈標記、經皮氧氣分壓(transcutaneous oxygen tension, PtcO₂) 與經皮二氧化碳分壓(transcutaneous carbon dioxide tension, PtcCO₂)訊號顯示,以及以 JavaScript 實作並整合至個人化報告之睡眠呼吸中止特異性缺氧負荷(sleep apnea-specific hypoxic burden, SASHB)計算模組。另分析 2021 至 2026 年六屆工作坊之完整前後測資料。各年度均採前測、專家講座與判讀回顧、後測及個人化回饋之訓練流程,參與者於相同雲端介面對該年度 PSG 個案進行前後兩次判讀,並以 30 秒 epoch 為單位與專家共識答案比對;該答案由四位資深睡眠技師完成兩輪判讀後,經多數決及諮詢專家裁決建立。共 147 筆完成前後測之年度紀錄納入睡眠分期分析,並以雙尾配對 Wilcoxon 符號等級檢定評估一致性變化。
    結果顯示,2021 至 2026 年各年度整體睡眠分期一致性於後測均高於前測,改善幅度介於 4.7 至 8.9 個百分點,其中 2021 至 2025 年之前後測差異達統計顯著。年度主題事件亦呈現相應改善,其中 2022 年腿動事件、2024 年呼吸事件及 2025 年 RSWA 整體一致性分別提升 4.5、14.7 及 21.5 個百分點。多數年資組亦呈現訓練後改善,顯示此訓練流程可適用於不同判讀經驗之參與者。
    綜合來說,既有雲端睡眠判讀平台可透過持續維運及臨床需求驅動之功能強化,支援不同疾病主題、訊號型態與判讀項目之訓練。專家講座、前後測與個人化回饋流程可穩定提升睡眠判讀一致性,並改善部分年度重點事件之判讀表現。SASHB 之整合使平台由傳統一致性回饋延伸至具臨床意義之指標運算。本研究成果具應用於睡眠技師繼續教育與跨機構判讀品質管理之潛力。

    Polysomnography (PSG) is an important tool for diagnosing and differentiating sleep disorders. Its interpretation relies on sleep technologists performing sleep staging and event scoring according to the American Academy of Sleep Medicine (AASM) guidelines. In practice, however, clinical PSG recordings often contain atypical waveforms, fragmented sleep, and complex events, so even with standardized rules different scorers may assign different labels to the same epochs or events. These scoring differences can affect sleep reports and derived clinical indicators. Prior studies have shown that a cloud-based platform combined with expert training can improve interscorer agreement of PSG scoring within a single year. However, the long-term operation of the platform, its application to different clinical themes across years, and its continued expansion to support additional scoring categories, signal types, and clinical metrics have not yet been systematically evaluated.
    Building on an existing cloud-based sleep scoring platform, this study carried out functional enhancements to meet the clinical and educational needs of the 2025 and 2026 nationwide sleep scoring workshops. These enhancements included the labeling and comparison of REM sleep without atonia (RSWA); support for loading and displaying Multiple Sleep Latency Test (MSLT) recordings together with light-off and light-on markers; the display of transcutaneous oxygen tension (PtcO₂) and transcutaneous carbon dioxide tension (PtcCO₂) signals; and a sleep apnea-specific hypoxic burden (SASHB) computation module implemented in JavaScript and integrated into the personalized report. In addition, the complete pre- and post-test data from six workshops held between 2021 and 2026 were analyzed. Each year followed a training protocol of pre-test, expert lecture and scoring review, post-test, and personalized feedback. Participants re-scored the same PSG recording for that year on the same cloud interface, and their results were compared with an expert consensus reference on a 30-second epoch basis; this reference was established by four senior sleep technologists who completed two rounds of scoring, followed by majority vote and adjudication by an expert consultant. A total of 147 annual participant records with completed pre- and post-tests were included in the sleep-staging agreement analysis, and changes in agreement were evaluated using a two-sided paired Wilcoxon signed-rank test.
    The results showed that overall sleep stage agreement was higher at post-test than at pre-test in every year from 2021 to 2026, with improvements ranging from 4.7 to 8.9 percentage points, and the pre-to-post difference reached statistical significance in the five years from 2021 to 2025. Agreement for the theme-specific events also improved: overall agreement for limb movement events in 2022, respiratory events in 2024, and RSWA in 2025 increased by 4.5, 14.7, and 21.5 percentage points, respectively. Most seniority groups also showed improvement after training, supporting the applicability of the training protocol across different levels of scoring experience.
    In summary, an existing cloud-based sleep scoring platform can support scoring training across different disease themes, signal types, and scoring items through sustained operation and clinically driven functional enhancement. The training protocol, comprising expert lectures, pre- and post-tests, and personalized feedback, can improve the scoring agreement and enhance scoring performance for some key events. The integration of SASHB extends the platform beyond agreement-based feedback to the automated computation of a clinically meaningful index. These findings support the potential use of the platform in continuing education for sleep technologists and cross-institutional scoring quality management.

    摘要 i Abstract iii 誌謝 vi Contents viii List of Tables x List of Figures xi Chapter 1 Introduction 1 1.1 Clinical Burden of Sleep Disorders and Polysomnography 1 1.2 Sleep Scoring Items and Objective Sleep Metrics 3 1.3 Inter-Scorer Reliability 4 1.4 Remote Scoring Training and the Need for a Cloud Platform 5 1.5 Limitations of the Apnea–Hypopnea Index and Emerging Hypoxic-Burden Metrics 7 1.6 Prior Platform Research and Study Positioning 8 1.6.1 Development Trajectory of the Platform 9 1.6.2 Inherited Platform Scope and Study Contributions 10 1.7 Research Objectives 11 Chapter 2 Platform Enhancement 12 2.1 System Maintenance Requirements and Design Principles 12 2.2 System Architecture and Data Flow 13 2.3 Online PSG Scoring Interface and Data Storage 15 2.4 Expert Consensus Integration and Individualized Report Generation 16 2.5 Multi-Year Functional Evolution 20 2.6 Functional Enhancements in 2025–2026 21 2.6.1 Integration of RSWA and MSLT Functions in 2025 21 2.6.2 New Signal Channels and Interface Functions in 2026 22 2.6.3 SASHB Module Integration 24 Chapter 3 Workshop and Evaluation Methods 26 3.1 Annual Workshop Training Protocol 26 3.2 Annual Training Cases and Scoring Themes 28 3.3 Establishment of the Expert Consensus Reference 31 3.4 Methods for Evaluating Scoring Agreement 33 3.4.1 Sleep Stage Agreement 33 3.4.2 Respiratory Event Agreement 34 3.4.3 Arousal, SpO₂ Desaturation, and Limb-Movement Agreement 35 3.4.4 RSWA Event Agreement 35 3.4.5 Summary of Agreement-Computation Definitions 36 3.5 Hypoxic-Burden Computation Method 37 3.5.1 Algorithm Overview 37 3.5.2 Description of Each Step 38 3.6 Statistical Analysis Methods 43 Chapter 4 Multi-Year Outcome Analysis 46 4.1 Agreement Changes in Common Scoring Categories 46 4.2 Agreement Changes by Sleep Stage 48 4.3 Training Effectiveness for the Specific Theme Events 51 4.3.1 2022 PLMS Theme: Limb-Movement Agreement 52 4.3.2 2024 Severe OSA Theme: Respiratory-Event Agreement 53 4.3.3 2025 Narcolepsy Theme: RSWA Agreement 55 4.3.4 Specific Themes and Training Effects 57 4.4 Training Outcomes by Participant Characteristics 58 4.4.1 Pre- and Post-Test Sleep-Staging Agreement by Scoring-Experience Group 58 4.4.2 Cumulative Participation Experience and Scoring Performance 60 4.5 2026 SASHB Integration and Results 62 4.5.1 Analysis Range and Included Participants 62 4.5.2 Results of the Derived Indices Calculated from the Expert Consensus Reference 63 4.5.3 Distribution of Clinical Indices Derived from Participant Scoring 64 4.5.4 Retrospective SASHB Computation for the 2024 Severe-OSA Case 67 Chapter 5 Discussion 71 5.1 Contributions of This Study in Platform Development 71 5.2 Clinical and Educational Value of the 2025-2026 Functional Enhancements 73 5.3 Implications for Clinical Education and Quality Control 75 5.4 Limitations 76 Chapter 6 Conclusions and Future Work 78 6.1 Conclusions 78 6.2 Future Work 80 References 81 Appendix A 85

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