研究目的: 輪班工作在高科技產業中為一種常態性的工作模式，而此一工作模式長期容易導致壓力的累積，也因此導致許多心理及生理上的疾病，如冠狀動脈心血管疾病、失眠、月經失調等疾病，但是其真正的機轉尚不清楚。較嚴重的冠狀動脈心血管疾病更容易造成猝死而嚴重影響生產力。本研究以中文版JCQ(Job Content Questionnaire)問卷瞭解輪班工作者之壓力，並探討與血中高敏感性C反應蛋白(high sensitivity C- reactive protein, hs-CRP)的關連性，進而預測預測輪班工作是否可能導致冠狀動脈心血管疾病之增加。
研究方法: 2005/07-2005/09於台南科工區某家公司配合其年度健檢進行本項研究，共有257位男性員工同意參與。先以問卷收集過去疾病史、年齡、抽菸狀況、教育程度、肥胖程度、運動狀況、血壓和飲酒量，並測量血中hs-CRP值，並以JCQ中文版評估工作壓力及相關變項。
研究結果:本研究共有257位男性員工參與，平均年齡為29.4±3歲，需要輪班工作有157人(61%)，在無塵室工作的有219人(85.2%)，學歷以專科(49.42%)及大學(34.63%)最多。使用卡方檢定評估輪班工作與工作壓力(以中文版JCQ問卷評估)間的關連性，輪班工作與Job control(JC)、Physical demand(PD)及Job strain(JS)相關(p<0.05)。再以邏輯式迴歸分析後發現輪班工作的JC、PD及JS較低，勝算比分別為0.42(95%CI=0.23-0.75)、0.44(95%CI=0.27-0.73)及0.44(95%CI=0.27-0.73)。在調整其他干擾因子後，以複邏輯氏迴歸分析發現只有JC在輪班工作較低(AOR=0.41,95%CI=0.19-0.86)。經過分層分析後發現在無塵室工作者的PD及JS比不在無塵室工作者高，校正勝算比分別為4.12(95%CI=1.69-10.08)及4.19(4.19,95%CI=1.71-10.25)。再以t-test及卡方檢定檢測hs-CRP與相關因子的關係發現肥胖的程度(BMI)、飯前血糖(Ac sugar)及喝酒與血清中hs-CRP相關(p<0.05)。以邏輯式迴歸分析後發現BMI較高及飯前血糖較高的血清中hs-CRP較高，勝算比分別為1.34(95%CI=1.15-1.56)及 0.05(95%CI=1.01-1.09)。在調整其他干擾因子後，以複邏輯氏迴歸分析發現BMI較高及飯前血糖較高者的血清中hs-CRP仍較高，勝算比分別為1.5(95%CI=1.24-1.82)及1.08(95%CI=1.03-1.14)。hs-CRP與輪班工作間無明顯統計相關，經過邏輯式迴歸分析後仍然無明顯統計相關。
結論:輪班工作者對自我工作可掌握的程度(JC)較低， PD 及JS則與無塵室工作有關，BMI較高及飯前血糖較高的血清中hs-CRP較高，但本研究發現輪班工作並不會導致hs-CRP上升。

Objective: The objective of this study is to evaluate whether shift workers have higher levels of plasma hs-CRP, a biomarker of cardiovascular diseases (particularly coronary artery diseases), than non-shift workers.
Methods: There were 257 male workers agreed to participate in this study. On each participant, data on the past medical history, age, smoking, education level, obesity, physical activity, blood pressure, and alcohol consumption were collected, and the plasma hs-CRP level was measured. The job stress was evaluated by Karasek’s demand model.
Results: A negative association between working in shift work and job control(JC), physical demand (PD)and job strain(JS) (p < 0.05).The JC was associated with an odds ratio (OR) of 0.42 (95% confidence interval [CI] =0.23-0.75). The shift work was also a negative predictor of the PD and JS (OR=0.44,95%CI=0.27-0.73, OR=0.44,95%CI=0.27-0.73). After adjusting other factors, the shift work was independent significant predictors of the JC (OR = 0.41, 95%CI = 0.19-0.86).
A positive association between body mass index (BMI) and plasma hs-CRP level (p < 0.05) and a positive association between Ac sugar and plasma hs-CRP were observed (p < 0.05).The BMI was associated with an odds ratio (OR) of 1.34 (95% confidence interval [CI] =1.15-1.56). The Ac sugar was also a positive predictor of the hs-CRP level (OR=1.05,95%CI=1.01-1.09). After adjusting other factors, the BMI (OR = 1.5 , 95%CI = 1.24-1.82) and the ac sugar (OR=1.08,95%CI=1.03-1.14)were independent significant predictors of the hs-CRP level.
Conclusion: The shift work was independent significant predictors of the JC. The BMI and the ac sugar were independent significant predictors of the hs-CRP level.

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